Course
Master Class Overview (00)
Animal-Free Safety Assessment
Master Class Overview (00)
Provides tips for navigating course modules as well as an overview of the AFSA Master Class and a high-level introduction to animal-free safety assessment. You can download a summary of this module content in PDF format from the Files section...
Module 1: Problem Formulation (01)
Animal-Free Safety Assessment
Module 1: Problem Formulation (01)
This module introduces the purpose and process of problem formulation as an important first step in any risk assessment. By determining the overall aim of the risk assessment, problem formulation provides the basis for planning and conducting the...
Module 2: Consumer Exposure (02)
Animal-Free Safety Assessment
Module 2: Consumer Exposure (02)
Safety assessments for consumer products, including cosmetics, are led by exposure, which means that assessment of exposure is the first step after problem formulation, and the exposure scenario and predicted exposure will inform the design of...
Module 3: Predictive Chemistry (03)
Animal-Free Safety Assessment
Module 3: Predictive Chemistry (03)
This module is intended to provide enough information to understand the principles behind the most common types of modelling used in chemical safety assessment. A summary of the content of this module is provided in the Files section below and...
Module 4A: Exposure-based Waiving (04a)
Animal-Free Safety Assessment
Module 4A: Exposure-based Waiving (04a)
Since safety assessments for consumer products, including cosmetics, are led by characterizing exposure, assessing exposure can affect the rest of the safety assessment. In fact, for some ingredients used at very low levels in a product, safe use...
Module 4B: Safety of Botanicals/History of Safe Use (04b)
Animal-Free Safety Assessment
Module 4B: Safety of Botanicals/History of Safe Use (04b)
“History of Safe Use” is applied to botanicals and botanical extracts (natural substances). It is a method of extrapolating relevant information from a long history of familiarity with the botanical or natural product to a derivative of that...
Module 5 - Bioactivity: In vitro Assay Synthesis (05)
Animal-Free Safety Assessment
Module 5 - Bioactivity: In vitro Assay Synthesis (05)
This module describes how bioactivity data is used in a safety assessment, introduces many different non-animal methods, and demonstrates how to compile this information into an assessment for different problem formulations, including...
Module 6 - Internal Exposure: Dosimetry (06)
Animal-Free Safety Assessment
Module 6 - Internal Exposure: Dosimetry (06)
In this module, we illustrate the biokinetic processes that govern chemical distribution in the body and describe the mathematical tools that are used to develop quantitative descriptions of chemical dose to be used in risk assessments. We also...
Module 8: Global Regulatory Environment (08)
Animal-Free Safety Assessment
Module 8: Global Regulatory Environment (08)
Regulatory requirements (and related testing and assessment guidelines and guidance) greatly impact the problem formulation of a chemical risk assessment, including cosmetics. To ensure that your risk assessment will ultimately be accepted in a...

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